Speedy Review Of The Most Effective Registry Cleaners | welcome ...

Registry cleaners have gone through quite an evolution in the last few years, and are capable of doing many more things than ever before. Each computer has a certain amount of memory which should be cleaned from time to time ? up until recently, this was not common knowledge. Cleaning your registry is very important in regard to proper PC optimization ? it will simply run faster. All but the most casual and infrequent users need to take positive action to ensure their machines do not become bogged down. Computers will collect files and data, so much so that it will slow down every process on your CPU. In this article, the best registry cleaners of 2012 are presented and reviewed.

Registry cleaners, specifically those in 2012, have many different features that you will appreciate. PC Registry Cleaner is one of these products. If you?re interested in a product that offers one click protection, you will definitely find it with this innovative cleaner. Like a few other similar products, this one has been targeted to the user with limited knowledge of PCs. So, of course the programming approach reflects that targeting so as to reduce confusion and frustration. People that have used PC Registry Cleaner 2012 have mentioned that it does not have status indicators which could be problematic. For instance, if your computer is having problems in a certain area, there is no status indicator to tell you how bad the situation actually is. I often had computer problems before and it was really a big obstacle in my work as an ultrasound technician, so I crafted evaluations on some registry cleaners that can help me resolve technical issues.

One of the hallmarks of user-friendliness is how easy the interface is to use and even for novices. Designed with what they call an ?intuitive? interface, PC Registry Cleaner can help anyone start protecting their computer right away. Advanced automation is a key feature with this software which allows you to schedule far in advance. Computers are notorious for collecting useless information on their system which will impede its ability to function. If you have not cleaned your registry in some time, this program might run much longer than you would anticipate the first time around. Basically, it is going through your computer, seeing what is there, and removing what is unnecessary.

CyberDefender is another interesting registry cleaner that you should consider, especially if you are looking for something simplistic. Definitely not a flaw in the design, it is simple to use. There is a market for very simple to use programs that offer the basic registry cleaning function. Designed for simplicity, automatic scans, and the scheduling feature, are not included with the software program. This program is obviously very basic and should appeal to in this manner. Registry cleaning does not have to cost an arm or a leg ? get this basic registry cleaner to do the job for a considerable discount. I don?t even need to invest so much from my ultrasound technician salary because of the amazing offers on registry cleaners. Online reviews will provide you with the information you need to purchase one of the best registry cleaners of 2012. You can use our article as reference material as well. The best approach here is to know or have an idea of what you want. You have to think about how much you want to spend, and then gauge that with your knowledge of technology. And if you don?t want extra features, don?t buy them as this would be a waste of your money.

Source: http://www.pfotm.org/speedy-review-of-the-most-effective-registry-cleaners/

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Video: Talking Numbers: Buy Viacom Pre-Earnings?

Greg Troccoli, The Chart Lab, and David Bank, RBC Capital Markets, discuss the Viacom trade ahead of the company's earnings release.

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Source: http://video.msnbc.msn.com/cnbc/46225535/

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Celebrity Real Estate - Curbed National

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Source: http://curbed.com/archives/2012/02/01/celebrity-real-estate-34.php

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Firefox 10

With Firefox 10, the latest in Mozilla's rapid releases of the independent, open-source browser, users don't get much in the way of new features, but developers get several new tools. And version 10 marks the start of its Extended Support Release, which will allow businesses to deploy the new browser to their enterprises with the comfort that Mozilla will support it with security updates for at least a year. Finally, Firefox 10 smoothes the update process for extensions, making them compatible by default, and letting them update themselves silently.

Previous releases have brought bigger changes that will be welcomed by many users. Last time performance was improved with Type Inference (a technique that vastly improves JavaScript speed), we got better Mac OS X Lion operation and appearance, better "Do Not Track" support, and improved HTML5 standard support. With Firefox 8, we got a Twitter search option, more WebGL support, and protection from drive-by add-on installations. Firefox 7 added better use of memory, addressing one of the most common complaints I've heard about Firefox over the past few years. It also sped up startup times, in which Firefox has long trialed competing browsers.

It still holds true that the big interface changes all came along in version 4. Mozilla started emulating Google's Chrome (free, 4.5 stars) Web browser in JavaScript speed and minimalist interface, as competitors Internet Explorer 9 (free, 4 stars) and Opera 11.50 (free, 4 stars) have.

Firefox 10 can nearly match Chrome on JavaScript speed, and holds its own when it comes to HTML5 support and a trimmed down interface that gives the Web page center stage. But when compared side-by-side with Chrome, Firefox falls just a bit short in terms of HTML5 support and whiz-bang features like Chrome Instant, which loads pages from your history before you even finish typing their addresses or search terms in the address bar.

Install
A simple 15MB download gets you the Firefox 10 Windows installer. When you run it you'll lose your old version of Firefox. The latest Firefox is available for Mac (31MB) and Linux (17MB) as well as for Windows 7, Vista, and XP?the last of which even Internet Explorer 9 (Free, 4 stars) can't claim. You can import bookmarks from any other installed browsers on first run, but setup is nearly as uncomplicated as it is for Chrome. Firefox also now makes it easy to choose a search provider other than Google, but surprisingly, not as easy as Chrome does. Recently, though, Mozilla started offering a Firefox for Bing version, which uses Microsoft's Web search built in.

It's more likely that you'll be updated to Firefox 10 automatically, though, since, starting with version 4, Firefox followed Google Chrome in yet another way: by automatically checking for and downloading each new version, and installing it the next time the browser starts. This has the benefit of keeping the majority of users on the latest version. To give the automatic updater a nudge, choose Help>About from the main Firefox menu dropdown.

The first time you run Firefox, you'll see the "Select Your Add-ons" dialog. This is so that you can see any add-ons that may have been installed unbeknownst to you by another app you installed. After this first extension approval, the browser will no longer allow third-party app installations to install Firefox extensions without your approval.

Interface
Firefox 10 brings one small new interface detail: No longer will the Forward button appear to the left of the site favicon unless you've already navigated Back. It's a detail, but it's nevertheless a sign that Mozilla designers are continually thinking about the most logical and efficient appearance a browser can present. Even Chrome, noted for its minimalist interface, still displays that useless forward button when there's no chance of its functioning.

Firefox's interface is in line with the trend of "less is more"?less space taken up by the browser frame and controls and more space for Web pages. The page tabs have moved above the address bar, and, as with Opera 11.60, there's just a single menu option in the form of the orange Firefox button at top left. You can re-enable the standard menus by hitting the Alt key.

The Mac version of Firefox integrates well with Apple's latest desktop operating system, Mac OS X Lion. Mozilla's browser supports the OS's two- and three-finger swiping gestures for moving between apps and pages in full screen, and the theme design matches Lion's toolbar and icon stylings.

The Home button has moved to the right of the search bar, and a bookmark button appears to the right of that. That bookmark button only appears when you don't want the bookmark toolbar taking up browser window space. This gives you one-click access to frequently needed Web addresses. But I wish that, like IE's star button, Firefox also let you see recent page history. You can still call up the full bookmark manager, which lets you do things like importing bookmarks from other browsers, search, and organize.

Firefox is one of the last remaining browsers to still use separate address and search boxes, which is good for those who like to keep those two activities separate. That doesn't mean, however, that a search won't work in the address bar, aka the "awesome bar." That tool, which drops down suggestions from your history and favorites whenever you start typing, was pioneered by Firefox and copied by all other browsers. Another tweak is that when one of its suggested sites is already open in a tab, you can click on a "Switch to tab" link, preventing you from opening more tabs unnecessarily?a useful tweak.

As part of its leading extensibility, Firefox has always been the browser most open to allowing different search providers, including specialized search like shopping, reference, or social. It was one of the first to support the OpenSearch format. The other popular browsers now do so, too, but Firefox can automatically detect search services on a page and let you add them from the search bar. With version 8, the social search category was bolstered by the built in addition of a Twitter search, making it easy to follow trending topics or to find Twitter personalities worth following.

Source: http://feedproxy.google.com/~r/ziffdavis/pcmag/~3/839o723yZF0/0,2817,2349494,00.asp

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Wall Street starts February strong on factory data, Greece (Reuters)

NEW YORK (Reuters) ? Stocks extended January's rally on Wednesday after upbeat global manufacturing data boosted sentiment and as Greece neared a long-delayed deal with private creditors.

The recent run of better-than-expected economic data around the world, though still not suggesting a booming expansion, has helped lift equity markets as investors move away from a worst-case scenario for the global economy.

An index of the U.S. manufacturing sector rose in January to its highest level since June, an industry group said, while China's factory sector expanded slightly, confounding expectations for a contraction. Germany recorded its first rise in manufacturing output in four months.

"The numbers aren't horrible, the trend continues that the news is OK," said Brian Battle, vice president of trading at Performance Trust Capital Partners in Chicago. "I think we're going to grind higher."

Optimism spurred gains in industrials, financials and basic materials, which rose between 1.1 percent and 1.7 percent. Caterpillar Inc (CAT.N), a company heavily exposed to global industry, rose 1.3 percent to $110.52 and was the biggest boost to the Dow industrials.

Trading volume was higher than it has been in recent days. Volume of the NYSE, Amex, and Nasdaq was 7.80 billion compared to its 20-day moving average of 6.97 billion. The wider participation comes after four down days when market movements were minimal and volume generally light.

Stocks also got a boost after Greek Finance Minister Evangelos Venizelos said talks between Athens and its private creditors were "one formal step away" from a deal needed to avoid a messy default. Such a deal would be a significant step in removing one of the biggest worries for investors.

U.S. and European banks rallied on the news. Bank of America Corp (BAC.N) gained 3.2 percent to $7.36 and Citigroup (C.N) rose 2.9 percent to $31.60.

The Dow Jones industrial average (.DJI) gained 83.55 points, or 0.66 percent, to 12,716.46. The Standard & Poor's 500 Index (.SPX) rose 11.67 points, or 0.89 percent, to 1,324.08. The Nasdaq Composite Index (.IXIC) climbed 34.43 points, or 1.22 percent, to 2,848.27.

After the S&P 500 rose 4.4 percent last month, some strategists see the benchmark approaching a short-term top. The index could be "near the upper end of a trading band," with a top around 1,350, according to John Manley, chief equity strategist at Wells Fargo Funds Management in New York.

"I'd rather own stocks than not, but on a year horizon," he said, indicating equities could pull back in the near term.

Homebuilder shares advanced after U.S. data showed construction spending surged in December to its highest level in more than 1-1/2 years. An index of housing stocks (.HGX) rose 1.8 percent. Shares in PulteGroup Inc (PHM.N), the second largest U.S. homebuilder, rose 5.1 percent to $7.83.

Amazon.com Inc (AMZN.O) slid 7.7 percent to $179.46 a day after the online retailer warned of a possible first-quarter loss and posted a steep drop in fourth-quarter profit.

According to Thomson Reuters data, with 228 companies having

reported results, 61 percent have beaten expectations - below the 70 percent beat rate of recent quarters.

Whirlpool Corp (WHR.N) surged 13.5 percent to $61.64 after giving an optimistic full-year outlook.

U.S. Treasuries prices fell on Wednesday as European risk assets improved, dampening demand for the safe-haven bonds, and as buying ebbed following a day of large month-end purchases.

Depressed Treasury yields, which point to caution on the part of investors, have been a reason for some to distrust a gain in stocks predicated on signs of an improving economy.

Facebook was expected to submit paperwork to regulators for a $5 billion initial public offering and selected Morgan Stanley (MS.N) and four other bookrunners to handle the IPO, sources told IFR, a unit of Thomson Reuters.

Morgan Stanley shares gained 4 percent to $19.39.

(Additional reporting by Rodrigo Campos; Editing by Padraic Cassidy)

Source: http://us.rd.yahoo.com/dailynews/rss/stocks/*http%3A//news.yahoo.com/s/nm/20120201/bs_nm/us_markets_stocks

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Drug approved to treat cystic fibrosis' root cause

WASHINGTON (AP) ? The first drug that treats the root cause of cystic fibrosis won approval Tuesday, offering a life-changing treatment for a handful of patients with the deadly illness and broader hope for thousands more patients with the inherited disease.

About 30,000 Americans live with cystic fibrosis, a disease that causes sticky mucus buildup in the lungs and other organs, leading to infections, digestive problems and death in young adulthood. The typical life expectancy is about 37 years, according to the Cystic Fibrosis Foundation.

The Food and Drug Administration approved Vertex Pharmaceuticals Inc.'s Kalydeco for patients with a rare form of the disease that affects just 1,200 people in the U.S., about 4 percent of affected population nationwide. These patients have a protein defect that prevents their cells from properly absorbing and excreting salt and water. Studies of the drug showed it significantly improved lung function and reduced other symptoms of cystic fibrosis.

"Even though this drug isn't for the majority of people, it proves that you can look at the mistake in the genes and design a drug in a rational way that will fix the problem," said Dr. Drucy Borowitz of the State University of New York at Buffalo, where she directs the cystic fibrosis program.

The twice-a-day pill is among the first drugs designed to a correct a specific genetic defect. Its development characterizes both the promise and challenges of that approach. Scientists first identified the gene that causes cystic fibrosis in 1989, but it took more than two decades and more than $75 million in outside funding to develop a drug to treat the disease.

Borowitz enrolled several of her patients in the key study for Kalydeco, which showed that patients taking the drug increased their lung strength more than 10 percent when compared with patients taking a placebo. Patients also had fewer infections and gained nearly seven pounds on average, a significant amount for patients who typically have trouble retaining weight. All patients in the study continued taking older medications that help loosen mucus.

"Two weeks after using the drug my lung tests were above average for a healthy 15-year-old who didn't have cystic fibrosis," said Nick Mangano, 17, a Borowitz patient who has been taking the drug for two years. Before starting on Kalydeco, Mangano said he was hospitalized for lung infections five times in four years. Now he says he usually recovers from a cold within a week or two.

"I don't really need medicine for it anymore, it's totally different," said Mangano, who is considering leaving Buffalo for college next year ? a step he hadn't previously considered because of his dependence on his family and physicians.

Only a few decades ago, children with cystic fibrosis seldom survived elementary school. Today, thanks to earlier diagnosis and new focus on diet and physical therapy, 47 percent live to be 18 or older.

The FDA approved the drug for patients 6 years old and up, though Vertex is also planning to study the drug in patients as young as 2 years old. Researchers hope that by using the drug earlier they will be able to prevent permanent lung damage, which is the primary cause of death for cystic fibrosis patients.

Mangano and others with the so-called G551D mutation have a defective protein that fails to balance the flow of chloride and water across the cell wall, leading to the buildup of internal mucus. The vast majority of cystic fibrosis patients have a different genetic defect, in which the protein does not reach the cell wall. Vertex is developing another drug to try and address that problem. Study data for that drug is expected later this year.

Kalydeco is part of a growing number of new medicines that target rare genetic variations found in subgroups of patients. Last year Pfizer launched a new lung cancer drug called Xalkori, which targets cancer linked to a genetic mutation found in less than 7 percent of patients.

Vertex executives said Kalydeco would cost $294,000 for a year's supply, placing it among the most expensive prescription drugs sold in the U.S. Specialty drugmakers are known to charge $300,000 or more for drugs that treat very small groups of patients.

"The drug is priced for the value it will deliver to this very small group of patients," Vertex Executive Vice President Nancy Wysenski told analysts.

Wysenski said Vertex would provide the medicine for free to people with no insurance and household income of $150,000 or less. The company will also cover 30 percent of copay costs for select patients who have insurance.

The FDA approved the drug in approximately three months, half the time usually needed for high-priority drugs.

After scientists identified the genetic sequence that causes cystic fibrosis in 1989, many experts hoped the disease could be cured by replacing the gene with a normal one. However, attempts at so-called gene therapy proved unsuccessful, and researchers began looking for ways to correct the genetic defect.

"I think it took the field about a decade to realize we had to look for other options," said Paul Negulescu, vice president of research at Vertex Pharmaceuticals.

In 1998, the Cystic Fibrosis Foundation approached Aurora BioSciences, now part of Vertex, to help screen potential drug candidates for a cystic fibrosis drug. In 2000, the foundation awarded the company more than $45 million to study and commercialize an experimental drug for the disease, the largest grant of its kind by a nonprofit disease group. To date, Vertex has received over $75 million in research and development funding from the Cystic Fibrosis Foundation. Vertex said it also spent hundreds of millions of dollars of its own money, though it did not specify the exact amount.

Cambridge, Mass.-based Vertex has only one other drug on the market, the hepatitis C drug Incivek, which launched last May.

Company shares rose $2.21, or 6.4 percent, to $36.95 in trading Tuesday.

The most common side effects with Kalydeco include headache, stomach ache, rash diarrhea and dizziness.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/bbd825583c8542898e6fa7d440b9febc/Article_2012-01-31-Cystic%20Fibrosis-New%20Drug/id-270a6c548dbb42199c9f31b98f82344f

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Synacor Files For IPO, Acquires HTML5 Cloud OS Carbyn For $1.1M

Online content, portal and comprehensive front-end technology solution Synacor filed its amended S-1 today for an IPO looking to raise $75 million. The filing revealed that this month Synacor acquired Carbyn, an HTML5 operating system that lets users put their files, applications and more in the cloud and access them from any device. It paid $1.1 million total for the company, ?$600,000 up front with $500,000 deliver in April 2013, and it hired 7 Carbyn employees.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/MF5BFtYb-XY/

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